The depression that resulted from this fact led her astray as a typical human being to become vulnerable to witches and familiars. However, her fate changed when she met Kaname Madoka.
And so, Homura came to know at least one person who stood by her side as a teacher, protector, and a loving friend. When Madoka was killed by Walpurgis Night, she wished she could save her best friend's life; an innocent wish of a girl who had nothing else but one true friend.
It is generally considered foolish to look at the past in regret. It doesn't even need to be said how foolish it is to wish for somebody to be brought back from the dead. After all, all living things die according to the irreversible balance of nature.
Therefore, Homura's wish completely neglected the laws of nature, which eventually led to her fall into hopeless despair.
Is Homura's wish to protect Madoka a selfless wish based on a pure and innocent heart, or was it a foolish wish since it defied nature itself?